Hormones and weight loss - eat more to lose more?

I've been reading about hormones and how they effect weight loss. Two hormones in particular are critical to eating, or over-eating: Ghrelin, and Leptin.

Ghrelin is a hormone produced by your stomach lining that triggers hunger, tells you to eat.
Leptin is a hormone produced by fat cells that signals satiety, or tells you to stop eating.

Here is an excellent article that covers these hormones and their role in weight loss in plain language.

Ghrelin is a very critical hormone, with receptors throughout your body, and is related not only to eating impulse, but also to learning and cognitive adaptation and helps to regulate neurons in your hippocampus. It is also an important factor in the production and regulation of the human growth hormone.

Leptin, from the Greek, Leptos, which means "thin," is an important horomone which not only tells us we are full after a meal, but helps to support your circulatory system, lungs, and bone health. Obese people often have developed a resistance to Leptin, which is believed to be induced by high-fructose interaction (a.k.a.: eating a lot of sugar,) meaning that people who are already overweight really, hormonally have a dampened / suppressed "fullness signal."

So how do these hormones effect weight loss? Other than by the obvious, turning on and off our eating urge?

Well, put simply, "dieting" really doesn't work, not in the traditional sense. Over-restricting your caloric intake unbalances Ghrelin and Leptin in your body and causes your body to go into fat storage mode. The goal is to keep your Ghrelin (eat) low and your Leptin (stop eating) high, but to do that you have to eat. This seems counter-intuitive, again. All weight loss plans involve calorie restriction.

In order to keep your hormonal balance, you need to reduce caloric intake but increase the volume and the frequency of meals. Again, sounds counter-intuitive, right? Eat more? Well, yes. Eat whole foods that are low-fat and high fiber. Fiber is a critical nutrient in feeling satisfied after a meal. Dietary fiber has so many health benefits it is worth a whole blog entry of it's own. Dietary fiber naturally reduces cholesterol, and delays the absorption of glucose  (sugar) which keeps your blood sugar more stable, thus allowing Leptin to work better and tell your body to stop eating. The real, metabolic reason fiber makes you feel fuller is because you are fuller -- dietary fiber has no calories, but it increases food volume. There you have it: reduce caloric intake but increase the volume and the frequency of meals.

Here is a list of high-fiber foods from the Mayo Clinic.

So, that's the big secret. Eat more and you can lose weight better, you just need to follow a couple simple rules. Higher food volume, lower caloric value.